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What is Hepatitis B Virus / HBV? |
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Hepatitis B Virus / HBV is the pathogeny of Hepatitis B, belonging to the virus section of hepatitis. HBV patient as well as HBV carrier are infectant headstream, especially the latter one. HBV has severe infectivity, tiny wound or mucous membrane contact with puny blood with HBV virus might be infected, furthermore, there are many infectious means. The most usual mean is blood infect, for example by transfusion, injection and so on; Secondly, unprotected sex infect; Thirdly, infectant foods go through the enteron and cause infection can not be excluded; A pregnant woman can also transmit the disease directly to her baby; There is also a possibility that insect sting will cause infect. |
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What is ¡°Three Big Positive¡± and ¡°Three Small Positive¡±? |
HBV is a severe infectious disease which will threaten our health, once you were infected, then it will take long time to recover, be take bad time to time. Therefore, prevent and diagnoses jobs become more and more important. Nowadays, hospitals will usually test five terms of HBV, they are: HBsAG, Anti-HBs, HBeAG, Anti-HBe, Anti-HBc.
If the outcome of these five terms shows ¡°Three Big Positive¡±:
HBsAG(+), Anti-HBs( - ), HBeAG( + ), Anti-HBe( - ), Anti-HBc( + )
This outcome suggests Virus is increasing and has strong infectivity.
If the outcome of these five terms shows ¡°Three Small Positive¡±:
HBsAG(+), Anti-HBs( - ), HBeAG( - ), Anti-HBe( + ), Anti-HBc( + )
This outcome suggests:
1 .Acute HBV disease is recovering.
2. Chronic HBsAG carrier
3. Weak infectivity
4. A possibility of virus aberrance
5. Long-standing will cause cancer
resently, most used test means of clinic test is venous blood test, separate serum, ELISA method is some kind of wasting time and discommodious operation. HBV colloidal gold test which is produced by Blue Cross Bio-Medical(Beijing) Co., Ltd. can easily test HBV individually, accurately and sensitively. Recently, Another whole blood test HBV diagnostic test kit was produced by our company which can use whole blood or plasm as specimen, this product make the operation more convenience. It adapts to small clinic, epidemic prevention, health care, transfusion control, furthermore, it is the most ideal, convenience and economic product for self test.
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Code |
HBsAg |
HBsAb |
HBeAg |
HBeAb |
HBcAb |
Clinic Meaning |
1. |
+ |
- |
+ |
- |
+ |
Three Big Positive£ºsuggests acute or chronic HBV, virus is increasing rapidly with strong infectivity |
2. |
+ |
- |
- |
+ |
+ |
Three Small Positive: suggests ¢Ù acute HBV infected area has recovered ¢Ú virus is increasing slowly with lower infectivity ¢Û virus aberrance |
3. |
+ |
- |
- |
- |
+ |
4. |
- |
+ |
- |
- |
+ |
Suggests HBV was recovered and still has immunity |
5. |
- |
- |
- |
+ |
+ |
Suggests ¢Ù HBV was recovered ¢Ú recovered form acute HBV |
6. |
- |
- |
- |
- |
+ |
7. |
- |
+ |
- |
- |
- |
Suggests infected by HBV or transmitted by HBV bacterin, has immunity |
8. |
- |
+ |
- |
+ |
- |
Suggests ¢Ù HBV was recovered ¢Ú recovered form acute HBV |
9. |
+ |
- |
+ |
+ |
+ |
Suggests ¢Ù Changing form HBeAg to HBeAb ¢Ú test error |
10. |
+ |
+ |
- |
- |
+ |
Suggests ¢Ù changing form HBeAg to HBeAb ¢Ú virus aberrance ¢Û test error |
11. |
+ |
- |
+ |
- |
- |
Suggests early stage of acute HBV, strong infectivity. Might be ¡°Three Big Positive¡±, should be decided after diluting 30 times |
12. |
- |
- |
- |
- |
- |
Suggests there is no HBV antibody and has not been infected by HBV virus |
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What is hepatitis C virus (HCV)? |
Hepatitis C virus (HCV) was first definitively identified by molecular cloning of the virus genome in 1989, HCV was caused by Hepatitis C virus, and will risk health and life no less than HBV, the reasons are as follow: ¢Ù HCV disease is existing worldwide ¢Ú Easily develop into chronic hepatitis, and has close connection with hepatocirrhosis and liver cancer. HCV infection occurs in 78% - 94% infected liver transplant recipients. Since July 1st 1993 the Chinese government has screened all donated blood for HCV as well as HBV.
HCV is blood-borne, which means that it is contracted only through blood-to-blood contact. BLOOD-TO-BLOOD contact includes: blood transfusions, tattoos, e.g.: drug use, passage of mother to unborn, or shared razors.
In the majority of cases HCV infection gives rise to acute HCV, chronic HCV, hepatocirrhosis and liver cancer. There is also someone who is healthy but still HCV carrier. Almost all patients develop a vigorous antibody and cell-mediated immune response which fails to clear the infection but may contribute towards liver damage. Most flavivirus infections are cytopathic, but this has not been directly tested in the case of HCV since the virus cannot be cultured. HBV disease usually start without any obvious symptom, in some typical acute HCV case, HCV antibody will become positive after one month or more. If this positive last for four months then it becomes chronic HCV disease, at least 50% - 75% cases of HCV infection become chronic hepatitis and will become hepatocirrhosis or liver cancer at last.
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Why these who takes HCV vaccine having Negative HCV antibody? |
| Some kind of person will not have antibody even if they have had HCV vaccine, but some others will have HCV antibody, if the concentration of HCV antibody can not reach the test requirement, the test will show negative outcome. |
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