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What is a-fetoprotein/ a- FP, AFP? |
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Alpha-fetoprotein (AFP) is normally produced by a developing fetus and begins to decrease soon after birth and is usually undetectable in the blood of healthy adults (except during pregnancy).AFP is a single chain glycoprotein with a molecular weight of approximately 70,000 Daltons. An elevated level of AFP strongly suggests the presence of liver cancer.
1. The AFP level is significantly elevated in the serum of the Primary liver cancer patient. Among them, about 77.1% patients have a AFP£¾500¦Ìg/l level, but 18% have no such elevation of AFP.
2. The AFP level of Viral hepatitis and Sclerosis of Liver patients is elevated differently. The level is £¼300¦Ìg/l, in fact, most patients have a level of £¼100¦Ìg/l£¬
The reason for the elevation is mainly due to the regeneration of destroyed liver cell makes itself have the ability of producing AFP. The AFP gets right again along with the recovery of the destroyed liver cell
3. The AFP in the serum of Germ embryonic tumor suffered patients is evidently elevated.
4. Three months later after pregnancy, the AFP level in the serum is elevated. This increasing will come to the highest point in her 7 to 8 months of pregnancy, which is below 400ng/L. Three weeks after birth, the AFP levels are decreased to normal range. If the AFP level is unexpected elevated, we should take the possibility of fetal nerve anomaly into consideration.
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What is precaution in the process of using one step FOB test? |
When one can see the Bloody stool by naked eyes, he is suggested to identify the Red cell under microscope. Because the antigen used in this product is specification only to the Hb of human being, the Occult Blood can be negative when the large quantity of red cell have not been destroyed.
If Tarry Stool exists, meanwhile, the concentration of Hb excess the scope of test, the result may be negative. To solve this problem, delude the specimen of stool enough.
Strip test: take out one drop of mixture from the specimen container, and drop it into the test tube with 1 ml distilled water. Test it by strip. If the specimen is tarry stool and negative even after dilute and that may be caused by the destroyed of mmunogenicity and lost of unity with antibody because Hb stays in the alimentary canall too long time. In this case, you may start a comprehensive diagnostic along with the clinical diagnostic.
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